Endocrine Abstracts

Context: Graves’ disease (GD) is the most common cause of hyperthyroidism. It occurs more commonly amongst women, smokers and patients with other autoimmune diseases or a family history of thyroid autoimmunity. Peak incidence occurs between 40 and 60 years of age but any age group may be affected. Vitamin D deficiency has been reported to link with a variety of autoimmune diseases. However, the relationship between the thyroid autoimmunity in GD and vitamin D deficiency i...

Objective and importance: Clinically nonfunctioning pituitary adenomas (NFPA) are the most common pituitary tumors after prolactinomas. The absence of clinical symptoms of hormonal hypersecretion can contribute to the late diagnosis of the disease.Clinical presentation: A 52-year-old man presented with muscle weakness, weight loss, fatigue and a long term history of depression. He had no headaches and no vision problems. Physical exam was unremarkable. N...

Context: Irisin is secreted by skeletal muscles into circulation and proposed to regulate energy homeostasis and hold therapeutic potential in diabetes and obesity.Objective: The aim of this study was to evaluate the effects of acute exercise training (6 week) on circulating plasma irisin in adult mens.Design and setting: This was a cross-sectional study conducted in a university hospital.Participants: A tota...

Context: Irisin, a newly discovered hormone, is secreted by skeletal muscles into circulation. It is proposed to regulate energy homeostasis and hold therapeutic potential in diabetes and obesity.Objective: We aimed to investigate the association of irisin and uncoupling protein 1 (UCP1) with gestational diabetes mellitus (GDM).Design and Setting: This was a cross-sectional study conducted in a university hospital.<p class="abs...

Purpose: Macrophage migration inhibitory factor (MIF) is a multi-functional cytokine which plays a role in metabolic and inflammatory processes. Increasing evidence suggests that there is a link between MIF and ovulation. We aimed to evaluate plasma MIF levels in women with polycystic ovary syndrome (PCOS) and to determine whether MIF levels differ between the follicular phase and mid-cycle of the menstrual cycle in eumenorrheic women.Methods: Ninety wom...